Picayune has a Council-Manager form of city government. The mayor and five council members are elected for four-year terms. The city manager is appointed by the city council. Officials of the City of Picayune are:

Mayor
Greg Mitchell

Councilmen
Jerry Bounds
Leavern Guy, Jr.
Donald L. Parker

Anna Bales Turnage

Larry Watkins
 

City Manager
Ed Pinero

City Clerk